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The scheme shows the principle of measuring the TOC via conductivity with miniTOC.
The miniTOC can be ordered as configuration with 4 inputs (miniTOC pro). With an additional software upgrade option the user can measure up to 3 loops sequentially.
An offline configuration is available to analyse single samples.
By using the offline mode of the miniTOC pro the system is also upgradable with an autosampler with 15 positions for 100 mL vials.
If the medium temperature is higher than 50 °C a heat exchanger is required.
If the medium pressure is higher than 1 bar a pressure transducer is required.
Software with 21 CFR part11 conformity for pharma applications.
The housing protects the miniTOC from dust deposits and water jets
Initiates alarm in case of inlet flow is zero.
Validation documents IQ/OQ and PQ for miniTOC (conform and non conform with 21CFR part 11 software.
extended conductivity of sample up to 10 µS/cm.
The miniTOC plus series offers the same parameter properties as the miniTOC, but is equipped with a robust control unit that guarantees IP54 protection as standard. This protection offers increased protection against the ingress of dust and splash water, making the devices versatile in use.
| Technical Specifications | |
|---|---|
| method & detection | UV oxidation (partial) & conductivity |
| sample volume flow | approx. 14 mL/min |
| time of measurement | 2 sec (online mode) | 1 min (offline mode) |
| measurement range | 0.5 to 1000 ppb |
| detection accuracy | ~0.5 ppb or 1 % (whatever is greater) |
| ports | 1 for sample, 1 for SST (basic) | 1 for sample, 3 for SST (pro) |
| related norms | USP <643>, EP 2.2.44, DIN EN 1484 |
| ambient parameters | relative humidity: 10 to 95 %, temperature: 10 to 45 °C |
| interface ports | analog, according to Namur NE43 |
| dimensions, weight, power | 300 x 200 x 500 mm, 14 kg, 110 - 230 V, 50 Hz, 60 Watt |
| Medium Requirements | |
|---|---|
| type of sample medium | pure or ultra pure water |
| medium conductivity | < 2 µS/cm (upgradable to < 10 µS/cm) |
| inlet pressure | < 1 bar |
| sample temperature | < 50 °C |
The miniTOC is used for pure and ultrapure water applications (e.g. WFI - water for injection).
The miniTOC operates according to USP 643, DIN EN 1494 and EP 2.2.44.
The miniTOC is only suitable for liquid media such as pure and ultrapure water, but not waste water or solids.
The miniTOC operates below a conductivity of 2 µS/cm, but can be designed to < 10 µS/cm on request.
The miniTOC uses the classic "flow-through" concept, in which the system oxidizes the sample using UV radiation and determines the TOC content in the sample via a conductivity difference measurement.
The miniTOC covers a TOC range from 0.5 to 1000 ppb.
The miniTOC is a classic online monitoring system, but can also be used in offline mode for measuring individual samples and can even be equipped with an autosampler.
Yes, the miniTOC can be calibrated easily and intuitively under the user's guidance. It also has an SST (system sustainibility test) function.
In addition to the calibration solutions, the pump hose must be changed at regular intervals and a new UV reactor inserted. After a subsequent calibration, the system is ready for use again.
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membraPure GmbH, Wolfgang-Kuentscher Str. 14, 16761 Hennigsdorf