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IONUS Ion Chromatograph

Using detection by conductivity


Saif AljubouriAlmurbat Group, Jordan
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"We purchased 2 systems in the last 5 years in two different countries. The system is accurate, effective, service is free and after sales service was always punctual and fast."


Designed for the analysis of anions and cations

  • This IONUS is suitable for the analysis of anions and cations in research, development and everyday routine.
  • The sample solutions are mostly water-based and may contain water-miscible organic solvents. A classic example is the analysis of (drinking) water according to EPA 300 Part A and B.
  • The advantage of IONUS is the compatibility with IC columns of all manufacturers and is compatible with all common eluents of anion and cation chromatography.
IONUS Ion Chromatograph Product View

Main technical specifications of the system​


  • In order to measure smaller concentration ranges in anion analysis, the instrument can be equipped with suppressor technology.
  • When applying without suppressor technique, it can happen that in the chromatogram there are negative as well as positive peaks for the individual substances or that the peak areas are very small due to very small conductivity differences.
  • In this case the external UV/VIS detector can provide a remedy by using indirect UV detection for light-absorbing eluents.
  • Another possibility is to use non-absorbent eluents for light-absorbing sample substances.
Flowchart: IONUS with suppressors
Options: Manual Injection Ionus

Manual injection port

Upon request each system can be supplied as manual configuration.

Options: Purge valve IONUS

Prime and purge valves

High pressure side prime and purge valves in eluent and reagent flow.

Options: Suppressor Ionus

Anion suppressor technique

Based on chemical processregeneration of suppressors with acid.

Options: Software Aracus

Software 21 CFR Part 11 compliance

Manual and automatic peak integration with integrated IQ/OQ procedure for software (only available with software Clarity).

Options: Detector Ionus

Indirect UV detection

The IONUS can be equipped with an additional UV/VIS detector.

Options: Column Thermostat Ionus

Column oven

Programmable thermostat for column (and suppressors).

Technical Specifications
methodion exchange chromatography of anions and cations in subsequent mode
manual injection20 µL, further injection loops upon request (50 µL, 100 µL, 200 µL)
autosampler2 racks, each of them with space for 48 vials (1.5 mL) or 12 vials (6 mL), sample cooling, loop 100 µL, 3 injection modes (full-loop, partial loop, microliter-pickup)
columnstainless steel / PEEK
temperature stability / range~ 0.5 °C / ambient up to 50 °C
detectionconductivity detector:
noise: 0.02 µS, 1s | linearity: < 1 s | range: 0 - 10 mS/cm
effective cell volume: 1 µL, conductivity block: 30 °C
isocratic pump systemmax. pressure: 400 bar | flow rate: 0.01 - 10.00 mL/min
reproducibility of flow rate: 0.1 % RSD at 100 µL/min
maximum operating pressure120 bar
control software & data aquisitionClarity (21 CFR part 11 compliant) or AminoPeak
dimensions, weight, power1000 x 350 x 375 mm*, 60 kg, 110 - 230 V, 50/60 Hz
*800 mm with opened main unit


Chromatographic separation of amino acids is performed by ion exchange chromatography, followed by detection of ions by conductivity or indirect UV measurement.

The samples for the IONUS are mainly water-based. Analyses according to EPA 300 Part A and Part B are standard.

The autsoampler includes 2x 48 sample vials, which have a capacity of 1.5 mL. For small sample volumes, inlets can be used for the sample vials to ensure proper sample collection.

The system has an alarm system with three different levels. At "yellow" the user is informed about a situation that is not critical, at "orange" a controlled shutdown of the system is performed and at "red" the system is secured against serious damage by emergency shutdown.

The system works with a pre-sequence, the analysis sequence and a post-sequence. When the measurement sequence is completed, the system goes into standby and runs a circulation to keep the system in an equilibrated state to be able to start a new measurement again as quickly as possible.

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Analysis of the amino acid composition of cell culture media
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