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Are you interested in developing new applications or do you have a general enquiry about amino acid analysis? Please contact us at sales@membrapure.de. We look forward to working with you to develop new and innovative solutions.
Below you will find all the applications that we can already cover with our amino acid analyzer and have developed either ourselves or in collaboration with customers or cooperation partners (industry and research institutions).
Amino acid analysis is an essential tool that makes it possible to reliably assess the composition and quality of products. Individual components can be precisely identified, adulterations detected and the highest quality standards ensured. Whether in research, in healthcare, e.g. in diagnostic laboratories, or in industrial production for use in quality control – the precise analysis of amino acids provides decisive findings for a wide range of applications.
For scientists, laboratories and companies with integrated quality control, precise amino acid quantification is often a challenge – especially when the amino acids to be measured are only present in very small quantities and highly sensitive measurement methods are required. Measured values must be reliably reproduced and reliably recorded. Our state-of-the-art amino acid analyzer ARACUS offers the necessary sensitivity and precision to meet these requirements – so we can guarantee reliable results in every area of application.
Efficient Amino Acid Analysis:
Precision with little effort Liquid chromatography-mass spectrometry (LC-MS/MS) is a typical analysis method for amino acids, but has some disadvantages compared to amino acid analysis with the ARACUS. Although it provides detailed insights, it is also associated with high maintenance costs, considerable operating costs and the need for specially trained personnel.
Our ARACUS amino acid analyser with classic post-column derivatization with ninhydrin or alternatively with O-phthaldialdehyde (OPA) represents an efficient alternative. This system is characterized by user-friendly handling, requires only minimal consumables and also impresses with its low-maintenance components. This can significantly reduce operating costs.
Thanks to its multiple application possibilities, amino acid analysis has established itself as an indispensable method in many fields of application. Whether in food analysis, clinical diagnostics or laboratory research – the exact determination of individual amino acids enables reliable quality control and the identification of possible adulterations.
Especially for research institutions, laboratories and companies with integrated quality control, it is essential to be able to detect amino acids even in the smallest quantities. Precise measurements and reproducible results are crucial here – a challenge that can be reliably mastered with the right analytical methods.
Development of Therapeutics
The development of pharmaceuticals to combat diseases can significantly benefit from amino acid analysis. It aids in identifying treatment targets during the screening of molecules and in clinical trials to ascertain effectiveness. Throughout the phases of biotherapeutics development, ARACUS stands capable of providing cost-effective, high-quality amino acid analysis, thereby lending crucial support to therapeutic development endeavors.
In the realm of food analysis, understanding the precise composition of food is crucial, and amino acid analysis stands as a pivotal element in quality control. ARACUS offers reliable and reproducible chemical analysis, which is paramount for safeguarding consumers, ensuring food safety, and fostering the innovation of new food products. Its application not only guarantees accurate food labeling but also acts as a deterrent against fraudulent practices.
Instances of meat fraud, where meat products are mislabeled or contain undisclosed fillers, are unfortunately common. For instance, additives like gelatin and water might be included without proper disclosure. Anticipating the emergence of lab-grown or alternative meats, precise identification and quantification of amino acids become imperative. ARACUS holds a pending patent specifically targeting meat fraud DE102016010887B3
When developing novel or improved food items, comprehensive analysis and comprehension of constituent elements are indispensable for quality assurance, particularly in the production of specialized medical foods. These specialized foods cater to individuals who require specific nutrients due to medical conditions not fulfilled by regular diets. Therefore, a robust amino acid analysis becomes essential to guarantee quality control and verify that the intended nutritional value is delivered.
Animal foods are formulated to meet the dietary requirements of animals, particularly livestock, with an optimized balance of amino acids in their feed contributing to better growth. Innovations in animal feed involve synthesizing amino acids that can be added to achieve a balanced amino acid profile without altering the overall protein content. Here again, precise amino acid analysis plays a vital role in closely monitoring feed composition, ensuring quality control, developing optimal formulas, maintaining safety standards, and deterring fraudulent practices.
Insights into this kind of exemplary work are provided by the publications “Amino acids profile of three different Egyptian goat breeds” and “The effects of phytobiotic feed additives on physical and chemical and functional and technological properties of rabbit meat,” which can be found in our literature section.
Amino acid analysis stands as an indispensable tool in comprehending the internal workings of the human body, crucial for diagnosing and monitoring various conditions. It necessitates swift, reliable, and consistent results from diverse sample types, with blood plasma being a particularly prominent medium besides urine and Cerebrospinal fluid in which ARACUS excels. Besides serving as a fundamental diagnostic aid, membraPure’s ARACUS amino acid analyzer has showcased efficacy in pinpointing specific medical conditions.
For instance, in identifying concurrent myocardial infarction and type 2 diabetes, precise measurement of homocysteine levels is imperative. Even slight elevations in homocysteine levels can signal a change in the disease state, underscoring the necessity of an accurate analyzer to detect such variations. Additionally, by utilizing an amino acid analyzer, alterations in the amino acid metabolome have been identified specifically in type 2 diabetes, potentially aiding in diagnosis and management. More detailed information can be found in the application notes “Method for determining amino acids in myocardial infarction and type 2 diabetes” and „Plasma Amino Acids Metabo-lomics’ Important in Glucose Management in Type 2 Diabetes“.
ARACUS exhibits proficiency in analyzing amino acids as biomarkers for metabolic disorders. Precisely measuring phenylalanine and tyrosine levels in blood can detect the harmful condition phenylketonuria (PKU) in children. Moreover, ARACUS holds a pending patent (DE102018108312A1) for the comprehensive amino acid analysis of inborn errors of metabolism in newborns. This holds particular significance for developing countries, offering the promise of reducing mortality rates in newborns and improving their overall health.
The need for an optimal environment and stringent quality control isn’t confined to final products or clinical settings alone. In laboratory-based research, amino acid analysis holds critical importance for nurturing and advancing biological samples. Even a slight imbalance in amino acid composition or an undetected introduction of contaminants can have detrimental effects on entire research projects and cell lines.
MembraPure has demonstrated the efficacy of its ARACUS amino acid analyzer in reliably and accurately determining amino acid levels in cell culture media. Additionally, ARACUS proves instrumental in assessing the amino acid balance in growth media and fermentation broth used for cultivating cells and microorganisms. This functionality ensures that deficiencies don’t compromise yield or product quality. Positive client feedback attests to various successful applications of ARACUS, further reinforcing its reliability and effectiveness.
Utilizing the appropriate amino acid analyzer to ascertain the thriving conditions of essential research organisms provides peace of mind. Ensuring they thrive in the correct environment and optimal conditions is paramount.
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